THE OPTIMIZATION OF AVICEL PH 101 AND MANNITOL IN Nigella sativa L. EXTRACT TROCHES BY SIMPLEX LATTICE DESIGN

Endang Dwi Wulansari, Endang Diyah Ikasari, Siska Prima

Sari


ABSTRACT

Nigella sativa L. Is one of herbs that can be used as antibacterical against Steptococcus pyogenes. We did the optimization of the avicel PH 101 and mannitol in Nigella sativa L. Troches by simplex lattice design (SLD). The result showed that the optimum proportion formula was 0.1 part of avicel PH 101 : 0.9 part of mannitol, with flow rate 11.5034 g/sec, moisture content 2.83%, compressibility 6.34%, hardness 4.26 kg, and friability 0.45%. The granule flow rate, moisture content, compressibility, hardness of troches with avicel PH 101 were bigger than troches with mannitol. The troches with mannitol, while the interaction of both ingredients had the biggest hardness of troches.

Key word : Nigella sativa, troches, optimization, simplex lattice design

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