MINIMUM INHIBITORY CONCENTRATION TEST OR CRUDE EXTRACT OF Nigella sativa Linn. SEEDS AND ITS FORMULATION IN LOZENGES

Endang Dwi Wulansari, Endang Diyah Ikasari, Lidya Sulaiman, Daniar Bayu Kusumo

Sari


Abstract

Nigella sativa Linn. Is well known in many biological activities. The aim of this study were to fine antibacterial activities of Nigella sativa Linn. Crude extract against Streptococcus pyogenes as Minimum Inhibitory Concentration (MIC) with dilution method and its formulation in lozenges dosage form. Taste perception test of the lozenges, was then taken to 30 volunteers. The result showed that MIC of Nigella sativa Linn. Crude extract was 3,92 mg/ml. From the formulation used of 5%, 10%, and 15% Nigella sativa Linn. Crude extract; performed a different physical charateristics on weight uniformity, friability, and hardness in each 5%, 10%, and 15% Nigella sativa Linn. Crude extract lozenges. The 20 volunteers agreed that a 5% Nigella sativa Linn. Crude extract lozenges was the most preferred taste.

Key words : Nigella sativa Linn., lozenges, MIC

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