THE EFFECT OF PROPYLENE GLYCOL CONCENTRATION ON THE PHYSICAL CHARACTERISTIC AND RELEASE RATE OF CAFFEINE IN GEL

Endang Diyah Ikasari, Milani

Sari


ABSTRACT

The aims of this research were to find if any the effects of the propylene glycol concentration on the physical characteristics of the gel which includes organoleptic, pH, viscosity, and of the caffeine releasing test within 360’ that includes the value of dissolution-%, DE-%, lag time. And diffusion coefficient.

Caffeine gel formulation consisted of F I (with 10% of propylene glycol addition), F II (with 20% of propylene glycol addition), F III (with 30% of propylene glycol addition), IV (without of propylene glycol addition) and the F V used as a positive control, an anti cellulite gel preparation that was  available in the market used. Based on physical characteristic test, it could be drawn that the increasing propylene glycol concentration increased clarity, pH, and gel viscosity. Increasing propylene glycol concentration also decreased dissolution-%, decreased DE-%, increased lag time and decreased diffusion coefficient. The physical characteristic test and the caffeine releasing test were analyzed by using the one-way ANOVA with 95% and probability (p=0.05) level SPSS.

Based on the results of the research, it could be concluded that the different propylene glycol concentration as humectants, affects significanthy to the physical characteristics, such as the pH and viscosity test, and to the caffeine releasing in gel, such as the dissolution-%, DE-%, lag time, and diffusion coefficient.

 

Keywords : Caffeine, gel, propylene glycol, lag time, dissolution

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